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Pathogenesis of peri-tumoral edema in intracranial meningiomas

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Abstract

Peri-tumoral edema in intracranial meningiomas occurs frequently and obviously impacts the morbidity and mortality of these predominantly benign neoplasms. Several causative factors (age, gender, volume, location…) have been unsuccessfully investigated. Despite recent progresses in metabolic imaging and molecular biology, the pathogenesis of peri-tumoral edema remains debated. Hypotheses include vascular endothelial growth factor, metalloproteinases and interleukins among many others. It is probable that this pathogenesis encompasses all these factors with different levels. The current review aims to shed the light on the investigated factors involved in the pathogenesis of peri-tumoral edema in meningiomas and identify the potential therapeutic targets.

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Abbreviations

PTBE:

Peri-tumoral brain edema

BBB:

Blood-brain barrier

VEGF:

Vascular endothelial growth factor

BNP:

Brain natriuretic peptide

AQP:

Aquaporin

MMP:

Metalloproteinases

HIF:

Hypoxia-inducible factor

IL:

Interleukin

WHO:

World Health Organization

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  1. Skull Base Surgery Unit, Department of Neurosurgery B, University Hospital of Lyon, Hospices Civils de Lyon, Lyon, France

    Moncef Berhouma, Timothee Jacquesson & Emmanuel Jouanneau

  2. Laboratory CREATIS - CNRS UMR5220 - INSERM U1206 – Lyon 1 University – INSA, Lyon, France

    Moncef Berhouma & François Cotton

  3. Department of Imaging, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France

    François Cotton

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Berhouma, M., Jacquesson, T., Jouanneau, E. et al. Pathogenesis of peri-tumoral edema in intracranial meningiomas. Neurosurg Rev 42, 59–71 (2019). https://doi.org/10.1007/s10143-017-0897-x

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